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Contrasting with a moderate elevation, a large increase in circulating homocysteine leads to an elevation of the plasma ratio of reduced aminothiols to total aminothiols for homocysteine and cysteine, which favors the occurrence of an antioxidant status (Andersson et al, 1995

The results for each treatment were expressed as fold control and compared between control and treated cells using analysis of variance (ANOVA)

Dehydration, often precipitated by diuretics or large-volume paracentesis, reduces effective renal perfusion and may impair renal ammonia excretion, leading to increased systemic ammonia levels

Heavy metals like mercury, lead, and cadmium have a high affinity for sulfur

doi: 10.1002/iub.1616

Overall, all these biomarkers are associated with neuropathologic mechanisms, including peripherally induced cytokine alterations, followed by bloodbrain barrier dysfunction with intrusive polyreactive autoantibodies, endothelial dysfunction and coagulopathy, increased reactivity of microglia, neuroinflammation and neuronal damage [114]